![]() ![]() Statistical analysis revealed an increase of Iduna activity started at an NPD1 concentration of 25 nanoMols (nM) in both types of human RPE cells. The researchers also noted the effect of NDP1 on Iduna activity peaked at six hours after the onset of the oxidative stress. In a series of experiments, the team found adding NPD1 to these cells one hour after a stroke was induced, resulted in an increased production and availability of the Iduna protein.įurther investigations identified Iduna as paramount in suppressing the production of a destructive protein called PARP. Led by Dr Bazan, researchers selected two different types of human retinal pigment epithelial (RPE) cells in separate cultures (ARPE-19 and primary RPE). Human cell trials Īs well as fish, other sources of omega fatty acids include chia seeds and walnuts. Previous trials have shown that NPD1 may offer retinal cell protection in the event of retinal degeneration. It is also necessary for the development of the nervous system, including vision. NPD1 is derived from the omega-3 DHA, which is enriched in the nervous system and has proved vital for proper brain function. "This protein, relatively little studied, turns out to be key for cell functional re-programing and subsistence." “These findings are significant because they show how NPD1, a lipid mediator made 'on demand,' modulates the abundance of a critically important protein (Iduna) toward cell survival," explained Dr Nicolas Bazan, Boyd professor and director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine. Iduna serves as a regulator of cell survival, halting neural cell death by repairing DNA and providing protection against a form of programmed cell death characteristic of stroke. Main findings from a paper conclude that NPD1, a signalling molecule made from the fish oil docosahexaenoic acid (DHA), enhances the production and availability of the protein Iduna. The gut-brain axis: Psychobiotic opportunity in 25 countries.Uncovering white spaces – Probiotics for a smooth menopause transition.Uncovering White Spaces – Probiotics for Pets.POSTbiotics – New Tools in Microbiome Modulation.After the pandemic: Business lessons and insights from 25 probiotic supplement e-markets.Wishing you a safe and happy hard-water fishing season. If you have any doubt whether the fish will survive release, plan to keep it as part of your allowable catch. In sub-zero weather, when water can freeze in seconds, it is important to protect a fish’s sensitive eyes and gill filaments. If possible, avoid exposing those parts to the freezing air by unhooking and releasing your fish in the water, or releasing your fish headfirst into the hole. If a fish is so big that you need to bring it out of the water in order to turn it around, or if you want to take its photo, try to keep it out of the water for as little time as possible. While the risks associated with releasing fish during summer’s warm water temperatures no longer exist, freezing temperatures can still impact the survival rates of fish that are released through holes in the ice. In general, many of the proper fish-handling tips that we covered in our article from this past summer still apply. DecemDon’t Freeze their Eyeballs and Gillsįor those fortunate to live in the parts of British Columbia where lakes freeze over every December, ice-fishing with friends and family is a great winter activity. ![]()
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